Potassium Carbonate → 2-[4-(2-Thienyl-methoxyiminomethyl)-phenoxy]-2-methyl-propionic acid

HRID 128472Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[N:22][O:23][CH3:24])[C:7]1[CH:21]=[CH:20][C:10]([O:11][C:12]([CH3:19])([CH3:18])[C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[N:22][O:23][CH3:24])[C:7]1[CH:21]=[CH:20][C:10]([O:11][C:12]([CH3:19])([CH3:18])[C:13]([OH:15])=[O:14])=[CH:9][CH:8]=1

Participants

Conditions

Temperature: 80 °C

Procedure

2.4 g of ethyl ester obtained in Example 23 and 1.05 g potassium carbonate dissolved in 75% aqueous ethanol (25 ml) are maintained at 80° C. for 5 hours. The alcohol is then evaporated off, the resulting material is made acidic and the acid precipitate is filtered off, to give a mixture of equivalent amounts of both stereoisomers which melts at 168° C.

Workup

customThe alcohol is then evaporated off
filtrationthe acid precipitate is filtered off
customto give
additiona mixture of equivalent amounts of both stereoisomers which melts at 168° C.

Sources & evidence

ORD record: ord-8191a86a12e2446a8a231b1d504c9c97
Source dataset: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04259509

Reaction notes

Loading…