反应详情

A mixture of 7.7 g (0.32 mole) of sodium hydride and 80 ml of DMF was stirred under an atmosphere of N2 and cooled with an ice-water bath. A solution of 33 g (0.32 mole) of 2,2-dimethylpropandiol in 100 ml of DMF was added dropwise. Stirring was continued until the gas evolution stopped, then a solution of 50 g (0.32 mole) 4-methoxybenzyl chloride was added. The reaction mixture was stirred at room temperature overnight. The resulting solution was poured into an ice-water mixture and the aqueous solution was extracted with ethyl ether three times. The ether solution was washed with H2O, saturated brine, and then dried over MgSO4.

1. temperaturecooled with an ice-water bath
2. stirringStirring
3. stirringThe reaction mixture was stirred at room temperature overnight
4. extractionthe aqueous solution was extracted with ethyl ether three times
5. washThe ether solution was washed with H2O, saturated brine
6. dry with materialdried over MgSO4