反应详情

温度

130 °C

A stock solution consisting of 0.0260 g (3.125×10-5 mol) of diacetato-bis-(tris-o-tolylphosphine)-palladium(II) in 50 ml of DMF is prepared under argon. 1 ml of stock solution, 4.63 g (25 mmols) of 4-bromobenzaldehyde, 1.83 ml (27.5 mmols) of acrylonitrile and 2.26 g (27.5 mmols) of anhydrous sodium acetate are added to 9 ml of DMF under argon, and the reaction mixture is stirred at 130° C. for 10 hours. 2.86 g (18.2 mmols) of 4-formylcinnamonitrile are obtained, corresponding to a yield of 73% of theory (conversion figure 29200; Pd content 0.0025 mol %).

1. customis prepared under argon