Hydrochloric Acid → HCID 66741538, compound

HRID 1284905Notes

Reaction equation

HRID 1284905 reaction equation
BrCCCCC[N:7]1[C:18](=[O:19])[C:17]2[N:15]([CH3:16])[CH:14]=[N:13][C:12]=2[N:10]([CH3:11])[C:8]1=[O:9].C(N(CC)CC)C.[ClH:27]>C1(C)C=CC=CC=1>[ClH:27].[NH:7]1[C:18](=[O:19])[C:17]2[N:15]([CH3:16])[CH:14]=[N:13][C:12]=2[N:10]([CH3:11])[C:8]1=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 23313664HCID 23313664, compound

Product 1

HCID 66741538HCID 66741538, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In toluene, 7.9 g of 1-(5-bromo-n-pentyl)theobromine, 5.0 g of N-benzyhydrylpiperazine and 4 g of triethylamine are stirred under reflux for 30 hours. The subsequent treatments are carried out in the same manner as described in Example 96. The obtained crude crystal is converted to a hydrochloride according to customary procedures to obtain 4.7 g of intended 1-}5-[4-benzhydrylpiperazinyl-(1)]-n-pentyl}-theobromine hydrochloride (the yield being 40.9%).

Workup

  1. temperatureunder reflux for 30 hours
  2. customThe obtained crude crystal

Sources & evidence

ORD record
ord-00598a3c283a439c969b9cf533c30d4c
Source dataset
uspto-grants-1986_01
Patent number
US04564617

Reaction notes

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