Methyl iodide → Methylketene methyl dimethylisopropylsilyl acetal

Temperature

0 °C

One g of diisopropyl amine was dissolved in 7.5 ml of THF at 0° C., and 7 ml of a 1.6M BuLi hexane solution was dropwise added. The mixture was stirred for 15 minutes at 0° C. The reaction solution was cooled to -78° C., and then 0.88 g (10 mmol) of methyl propionate was added. Thirty minutes later, 1.64 g (12 mmol) of dimethyl isopropyl silyl chloride was added thereto, and the mixture was stirred for 30 minutes. To the reaction solution, 1.9 ml of methyl iodide and 5 ml of pentane were added at -78° C., and then the reaction mixture was stirred at 0° C. for 30 minutes by means of ice bath. Then, the reaction mixture was left to stand overnight in a refrigerator. The reaction mixture was subjected to filtration, and the filtrate was distilled under reduced pressure, whereby 1.24 g (66%) of crude methylketene methyl dimethylisopropylsilyl acetal was obtained. NMR(CCl4)δ(ppm): 0.12(6H, s, (CH3)2Si), 0.96(6H, s, CH(CH3)2), 0.99(1H, s, CH(CH3)2), 1.40(3H, d, J=6 Hz, =CHCH3), 3.45(3H, s, OCH3), 3.57(1H, q, J=6 Hz, CH3CH=).

1. temperatureThe reaction solution was cooled to -78° C.
2. stirringthe mixture was stirred for 30 minutes
3. stirringthe reaction mixture was stirred at 0° C. for 30 minutes by means of ice bath
4. waitThen, the reaction mixture was left
5. waitto stand overnight in a refrigerator
6. filtrationThe reaction mixture was subjected to filtration
7. distillationthe filtrate was distilled under reduced pressure

ORD record

ord-7f8fb40ceec843b083cac810f7a58071

Source dataset

uspto-grants-1986_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04564674