Hydrochloric Acid → HCID 20186257, compound

HRID 1285028Notes

Reaction equation

HRID 1285028 reaction equation
[CH2:1]([CH:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21]C)=O)=[CH:14][CH:13]=2)[CH2:8]C1)[CH2:2][CH2:3][CH2:4][CH3:5].Cl.[CH3:24]COCC>>[OH:21][CH2:19][CH2:18][C:15]1[CH:14]=[CH:13][C:12]([CH:9]([CH3:8])[CH2:10][CH2:11][CH2:6][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:24]2)=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl Ether2×HCID 20186270HCID 20186270, compound

Product 1

HCID 20186257HCID 20186257, compound

Procedure

Next, 400 ml of (C2H5)2O was added to 6 g of Li[AlH4 ], and the resulting mixture was stirred. Thereto was very gradually added dropwise a (C2H5)2O solution including 36 g of the aforesaid methyl p-(4-pentylcyclohexyl)phenylacetate, and after completion of the addition, the thus obtained mixture was stirred at 30° C. or lower continuously for 3hours. The mixture was then poured into dilute hydrochloric acid and extracted with (C2H5)2O. After the (C2H5)2O was distilled off, the residue was recrystallized from n--C6H14 to obtain 4-[p-(2-hydroxyethyl)phenyl]pentylcyclohexane. The melting point of this compound was 44° to 46° C.

Workup

  1. additionafter completion of the addition
  2. stirringthe thus obtained mixture was stirred at 30° C. or lower continuously for 3hours
  3. extractionextracted with (C2H5)2O
  4. distillationAfter the (C2H5)2O was distilled off
  5. customthe residue was recrystallized from n

Sources & evidence

ORD record
ord-d8a84dac14644c8aa53b348d28d597ae
Source dataset
uspto-grants-1986_01
Patent number
US04564694

Reaction notes

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