Triethylamine → 2-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethylamino]-3-methyl-4H-imidazol-5-one

HRID 1285328Notes

Reaction equation

HRID 1285328 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH2:14])=[CH:7][CH:6]=1)[CH3:3].I.[CH3:16][N:17]1[CH2:21][C:20](=[O:22])[N:19]=[C:18]1SC.C(N(CC)CC)C>C(O)C>[CH3:3][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:18]2[N:17]([CH3:16])[CH2:21][C:20](=[O:22])[N:19]=2)=[CH:7][CH:6]=1)[CH3:1]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 202489501-Methyl-2-methylthio-imidazolin-4-one hydroiodide

Product 1

HCID 1784832192-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethylamino]-3-methyl-4H-imidazol-5-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(5-Dimethylaminomethylfuran-2-ylmethylthio)ethylamine (2.25 g), 1-methyl-2-methylthio-imidazolin-4-one hydroiodide (2.85 g) and triethylamine (3.635 g) were refluxed in ethanol (25 ml) for 4 hours.

Sources & evidence

ORD record
ord-e509d6c851424fabb3fce6a44bbf29d4
Source dataset
uspto-grants-1986_01
Patent number
US04567176

Reaction notes

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