Triethylamine → HCID 178516767, compound

HRID 1285330Notes

Reaction equation

HRID 1285330 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17]N)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.I.CS[C:22]1[NH:23][CH2:24][C:25](=[O:27])[N:26]=1.C(N(CC)CC)C>C(O)C>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][C:22]3[NH:23][CH2:24][C:25](=[O:27])[N:26]=3)[CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 146251023-({4-[(Piperidin-1-yl)methyl]pyridin-2-yl}oxy)propan-1-amineHCID 178503565HCID 178503565, compound2×

Product 1

HCID 178516767HCID 178516767, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-(4-Piperidinomethylpyrid-2-yloxy)propylamine (2.57 g), 2-methylthio-imidazolin-4-one hydroiodide (2.60 g) and triethylamine (2.18 g) were refluxed in ethanol (20 ml) for 5 hours. The mixture was refluxed for a further hour in the presence of additional 2-methylthio-imidazolin-4-one hydroiodide (2.60 g) to ensure completion.

Sources & evidence

ORD record
ord-616a912a1d5842749bd25e058f241b3a
Source dataset
uspto-grants-1986_01
Patent number
US04567176

Reaction notes

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