反应详情

5.0 Grams of 6-(1-hydroxy-2-piperazinylbutyl)-3,4-dihydrocarbostyril, 3.5 g of p-bromonitroaniline, 1.8 g of potassium carbonate and 0.2 g of copper powder were mixed in 60 ml of 3-methoxybutanol and refluxed by heating for 5 hours. The reaction mixture was filtered and the mother liquor was concentrated by distillation under a reduced pressure to dryness. The residue thus obtained was extracted with methanol-chloroform and the solvent was removed by distillation to obtain a residue. The residue was purified and separated by a preparative silica-gel thin layer chromatograph to obtain 0.21 g of 6-{1-hydroxy-2-[4-nitrophenyl)-1-piperazinyl]butyl}-3,4-dihydrocarbostyril in yellow powdery crystals.

1. temperaturerefluxed
2. temperatureby heating for 5 hours
3. filtrationThe reaction mixture was filtered
4. concentrationthe mother liquor was concentrated by distillation under a reduced pressure to dryness
5. customThe residue thus obtained
6. extractionwas extracted with methanol-chloroform
7. customthe solvent was removed by distillation
8. customto obtain a residue
9. customThe residue was purified
10. customseparated by a preparative silica-gel thin layer chromatograph