反应详情

To 9.4 g of magnesium stirred in 350 ml of diethyl ether was added 60.4 g of iodoethane over 30 minutes to produce a mildly refluxing reaction mixture. The reaction mixture was refluxed for an additional hour, and then 23 g of the methyl ester of 4-methyl-3-cyclohexene-1-carboxylic acid in 20 ml of diethyl ether was added dropwise while maintaining gentle reflux. The reaction mixture was refluxed for an additional 1/2 hour, quenched with water, and extracted with diethyl ether; the ether extract was washed with saturated NaCl solution, dried (MgSO4), and stripped to yield an oil, which upon distillation gave 23.2 g of product, b.p. 90° C. (1 mm).

1. customto produce
2. temperaturea mildly refluxing
3. customreaction mixture
4. temperatureThe reaction mixture was refluxed for an additional hour
5. temperaturewhile maintaining gentle reflux
6. temperatureThe reaction mixture was refluxed for an additional 1/2 hour
7. customquenched with water
8. extractionextracted with diethyl ether
9. extractionthe ether extract
10. washwas washed with saturated NaCl solution
11. dry with materialdried (MgSO4)
12. customto yield an oil, which
13. distillationupon distillation