3-Bromopyridine → Biphenyl

HRID 1285709Notes

Reaction equation

HRID 1285709 reaction equation
Brc1cccnc1.CC(N)CCc1ccccc1>CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C(C)(C)C)(C(C)(C)C)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(C)(=O)=O)c(C(C)C)c1.CN1CCCN2CCCN=C12.CS(C)=O>CC(CCc1ccccc1)Nc1cccnc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 311601-Methyl-3-phenylpropylamine

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 311601-Methyl-3-phenylpropylamineHCID 43190526N-(4-phenylbutan-2-yl)pyridin-3-amine

Reagents, catalysts & solvents 3

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneReagentHCID 178439022HCID 178439022, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-77cfd6a0189b4bcab81a71a919bea729
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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