反应详情

Methyl 2-methoxy-4-(1-acetyl-4-piperidyloxy)phenylacetate (0.18 g, 0.56 mmol) was dissolved in THF (5 ml) and treated with lithium hydroxide (0..67 ml of a 1M aqueous solution, 0.67 mmol). The mixture was stirred at ambient temperature for 4 hours, then treated with an additional 0.2 ml of 1M lithium hydroxide. The mixture was heated at 60° for 6 hours, then cooled and concentrated in vacuo. The residue was acidified with 1M HCl, and extracted with ethyl acetate. The combined ethyl acetate layers were extracted with saturated aqueous sodium carbonate. The combined sodium carbonate layers were acidified with concentrated HCl and extracted with ethyl acetate. The combined ethyl acetate layers were dried over sodium sulfate, filtered, and evaporated to dryness in vacuo to give 2-methoxy-4-(1-acetyl-4-piperidyloxy)phenyl-acetic acid.

1. temperatureThe mixture was heated at 60° for 6 hours
2. temperaturecooled
3. concentrationconcentrated in vacuo
4. extractionextracted with ethyl acetate
5. extractionThe combined ethyl acetate layers were extracted with saturated aqueous sodium carbonate
6. extractionextracted with ethyl acetate
7. dry with materialThe combined ethyl acetate layers were dried over sodium sulfate
8. filtrationfiltered
9. customevaporated to dryness in vacuo