Benzenesulfonamide → Biphenyl

HRID 1285974Notes

Reaction equation

HRID 1285974 reaction equation
Brc1cccnc1.NS(=O)(=O)c1ccccc1>CC(C)(C)P(C1=CC=C[CH]1[Fe][CH]1C=CC=C1[P](C(C)(C)C)(C(C)(C)C)->[Pd]1(<-[NH2]c2ccccc2-c2cccc[c]21)[O]S(C)(=O)=O)C(C)(C)C.CN(C)C(=NC(C)(C)C)N(C)C.CS(C)=O>O=S(=O)(Nc1cccnc1)c1ccccc1

Participants

9

Reactant 2

HCID 7370BenzenesulfonamideHCID 122863-Bromopyridine

Product 4

HCID 7095BiphenylHCID 7370BenzenesulfonamideHCID 122863-BromopyridineHCID 339079N-3-Pyridylbenzenesulfonamide

Reagents, catalysts & solvents 3

HCID 35715812-tert-Butyl-1,1,3,3-tetramethylguanidineReagentHCID 178454865HCID 178454865, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-8e4dbe6ba4024865815fa9cac758e8b2
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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