3-Bromopyridine → Biphenyl

HRID 1286049Notes

Reaction equation

HRID 1286049 reaction equation
Brc1cccnc1.Nc1ccc(-c2ccccc2)cn1>CC12CC3(C)OC(C)(CC(C)(O1)[P]3(c1ccccc1)->[Pd]1(<-[NH2]c3ccccc3-c3cccc[c]31)[O]S(C)(=O)=O)O2.CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.CS(C)=O>c1ccc(-c2ccc(Nc3cccnc3)nc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 1050975-Phenyl-2-pyridinamine

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 1050975-Phenyl-2-pyridinamineHCID 175070979HCID 175070979, compound

Reagents, catalysts & solvents 3

HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineReagentHCID 178420943HCID 178420943, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-01c53079190449d0b1489aa6770c8112
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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