3-Bromopyridine → Biphenyl

HRID 1286064Notes

Reaction equation

HRID 1286064 reaction equation
Brc1cccnc1.Nc1ccc(-c2ccccc2)cn1>CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1[P](C1CCCCC1)(C1CCCCC1)->[Pd]1([Cl])<-[NH2]c2ccccc2-c2cccc[c]21.CN(C)C(=NC(C)(C)C)N(C)C.CS(C)=O>c1ccc(-c2ccc(Nc3cccnc3)nc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 1050975-Phenyl-2-pyridinamine

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 1050975-Phenyl-2-pyridinamineHCID 175070979HCID 175070979, compound

Reagents, catalysts & solvents 3

HCID 35715812-tert-Butyl-1,1,3,3-tetramethylguanidineReagentHCID 178458463HCID 178458463, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-1d8db4ebe5ca4ae6865e23d6e25ef958
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

Loading…