3-Bromopyridine → Biphenyl

HRID 1286095Notes

Reaction equation

HRID 1286095 reaction equation
Brc1cccnc1.Nc1ccc(-c2ccccc2)cn1>CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C(C)(C)C)(C(C)(C)C)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(C)(=O)=O)c(C(C)C)c1.CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C.CS(C)=O>c1ccc(-c2ccc(Nc3cccnc3)nc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 1050975-Phenyl-2-pyridinamine

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 1050975-Phenyl-2-pyridinamineHCID 175070979HCID 175070979, compound

Reagents, catalysts & solvents 3

HCID 35138512-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amineReagentHCID 178439022HCID 178439022, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-97da0bbd710f4520a607f64c8dddbb73
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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