3-Bromopyridine → Biphenyl

HRID 1286429Notes

Reaction equation

HRID 1286429 reaction equation
Brc1cccnc1.OCCCc1ccccc1>CC12CC3(C)OC(C)(CC(C)(O1)[P]3(c1ccccc1)->[Pd]1(<-[NH2]c3ccccc3-c3cccc[c]31)[O]S(C)(=O)=O)O2.CN1CCCN2CCCN=C12.CS(C)=O>c1ccc(CCCOc2cccnc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 31234Benzenepropanol

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 31234BenzenepropanolHCID 97356607HCID 97356607, compound

Reagents, catalysts & solvents 3

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneReagentHCID 178420943HCID 178420943, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-6b23a9463fe84d2d898e2f0c70ebe223
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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