Thiophenol → Biphenyl

HRID 1286617Notes

Reaction equation

HRID 1286617 reaction equation
Brc1cccnc1.Sc1ccccc1>CC(C)(C)[P](C(C)(C)C)(C(C)(C)C)->[Pd]1([Cl])<-[NH2]c2ccccc2-c2cccc[c]21.CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C.CS(C)=O>c1ccc(Sc2cccnc2)cc1

Participants

9

Reactant 2

HCID 7969ThiophenolHCID 122863-Bromopyridine

Product 4

HCID 7095BiphenylHCID 7969ThiophenolHCID 122863-BromopyridineHCID 38136103-PHENYLTHIOPYRIDINE

Reagents, catalysts & solvents 3

HCID 35138512-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amineReagentHCID 178454887HCID 178454887, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-781d08b7c6b84490a9ab7568325aadd5
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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