Thiophenol → Biphenyl

HRID 1286624Notes

Reaction equation

HRID 1286624 reaction equation
Brc1cccnc1.Sc1ccccc1>CC(C)(C)N=P(N1CCCC1)(N1CCCC1)N1CCCC1.CC12CC3(C)OC(C)(CC(C)(O1)[P]3(c1ccccc1)->[Pd]1(<-[NH2]c3ccccc3-c3cccc[c]31)[O]S(C)(=O)=O)O2.CS(C)=O>c1ccc(Sc2cccnc2)cc1

Participants

9

Reactant 2

HCID 7969ThiophenolHCID 122863-Bromopyridine

Product 4

HCID 7095BiphenylHCID 7969ThiophenolHCID 122863-BromopyridineHCID 38136103-PHENYLTHIOPYRIDINE

Reagents, catalysts & solvents 3

HCID 3856267tert-Butylimino-tri(pyrrolidino)phosphoraneReagentHCID 178420943HCID 178420943, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-66d2ed3c77194a16866cbec98472d3d8
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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