Thiophenol → Biphenyl

HRID 1286645Notes

Reaction equation

HRID 1286645 reaction equation
Brc1cccnc1.Sc1ccccc1>CC(C)(C)P(C1=CC=C[CH]1[Fe][CH]1C=CC=C1[P](C(C)(C)C)(C(C)(C)C)->[Pd]1(<-[NH2]c2ccccc2-c2cccc[c]21)[O]S(C)(=O)=O)C(C)(C)C.CN1CCCN2CCCN=C12.CS(C)=O>c1ccc(Sc2cccnc2)cc1

Participants

9

Reactant 2

HCID 7969ThiophenolHCID 122863-Bromopyridine

Product 4

HCID 7095BiphenylHCID 7969ThiophenolHCID 122863-BromopyridineHCID 38136103-PHENYLTHIOPYRIDINE

Reagents, catalysts & solvents 3

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneReagentHCID 178454865HCID 178454865, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-a6b6a74413874948a61ef480cb4b8918
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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