Water → Biphenyl

HRID 1286796Notes

Reaction equation

HRID 1286796 reaction equation
Brc1cccnc1.CC1(C)OB(c2cnn(Cc3ccccc3)c2)OC1(C)C.O>CN(C)C(=NC(C)(C)C)N(C)C.CS(=O)(=O)[O][Pd]1(<-[NH2]c2ccccc2-c2cccc[c]21)<-[P](C1=CC=C[CH]1[Fe][CH]1C=CC=C1P(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1.CS(C)=O>c1ccc(Cn2cc(-c3cccnc3)cn2)cc1

Participants

10

Reactant 3

HCID 962WaterHCID 122863-BromopyridineHCID 27347711-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 27347711-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 42628230HCID 42628230, compound

Reagents, catalysts & solvents 3

HCID 35715812-tert-Butyl-1,1,3,3-tetramethylguanidineReagentHCID 178505365HCID 178505365, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-c4a0ba58ada3465c96117406e38b72b9
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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