Water → Biphenyl

HRID 1286843Notes

Reaction equation

HRID 1286843 reaction equation
Brc1cccnc1.CC1(C)OB(c2cnn(Cc3ccccc3)c2)OC1(C)C.O>CC(C1=C([P](C2CCCCC2)(C2CCCCC2)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(C)(=O)=O)[CH]([Fe][CH]2C=CC=C2)C=C1)P(C(C)(C)C)C(C)(C)C.CN1CCCN2CCCN=C12.CS(C)=O>c1ccc(Cn2cc(-c3cccnc3)cn2)cc1

Participants

10

Reactant 3

HCID 962WaterHCID 122863-BromopyridineHCID 27347711-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 27347711-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 42628230HCID 42628230, compound

Reagents, catalysts & solvents 3

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneReagentHCID 178437371HCID 178437371, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-6d31ce7f9c9b476098713c0f1487bb01
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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