Water → Biphenyl

HRID 1286853Notes

Reaction equation

HRID 1286853 reaction equation
Brc1cccnc1.CC1(C)OB(c2cnn(Cc3ccccc3)c2)OC1(C)C.O>CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.CS(=O)(=O)[O][Pd]1(<-[NH2]c2ccccc2-c2cccc[c]21)<-[P](c1ccccc1N1CCOCC1)(C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3.CS(C)=O>c1ccc(Cn2cc(-c3cccnc3)cn2)cc1

Participants

10

Reactant 3

HCID 962WaterHCID 122863-BromopyridineHCID 27347711-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 27347711-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 42628230HCID 42628230, compound

Reagents, catalysts & solvents 3

HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineReagentHCID 178505364HCID 178505364, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-7829b74a87784a8a9c727a84591e16fd
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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