3-Bromopyridine → Biphenyl

HRID 1287017Notes

Reaction equation

HRID 1287017 reaction equation
Brc1cccnc1.CCOC(=O)/C=C/c1ccccc1>CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C2CCCCC2)(C2CCCCC2)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(C)(=O)=O)c(C(C)C)c1.CN1CCCN2CCCN=C12.CS(C)=O>CCOC(=O)/C=C(\c1ccccc1)c1cccnc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 637758Ethyl Cinnamate

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 637758Ethyl CinnamateHCID 178470870HCID 178470870, compound

Reagents, catalysts & solvents 3

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneReagentHCID 178439017HCID 178439017, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-63bf3444b88940b09de5565178642132
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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