3-Bromopyridine → Biphenyl

HRID 1287116Notes

Reaction equation

HRID 1287116 reaction equation
Brc1cccnc1.C#Cc1ccc(CCCC)cc1>CC(C)(C)N=P(N1CCCC1)(N1CCCC1)N1CCCC1.CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C2CCCCC2)(C2CCCCC2)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(C)(=O)=O)c(C(C)C)c1.CS(C)=O>CCCCc1ccc(C#Cc2cccnc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 27751321-Butyl-4-ethynylbenzene

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 27751321-Butyl-4-ethynylbenzeneHCID 178440834HCID 178440834, compound

Reagents, catalysts & solvents 3

HCID 3856267tert-Butylimino-tri(pyrrolidino)phosphoraneReagentHCID 178439017HCID 178439017, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-a3d32473096b4ff4867d9db7e56b20ec
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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