3-Bromopyridine → Biphenyl

HRID 1287128Notes

Reaction equation

HRID 1287128 reaction equation
Brc1cccnc1.C#Cc1ccc(CCCC)cc1>CC(C)(C)N=P(N1CCCC1)(N1CCCC1)N1CCCC1.CC(C)(C)P(C1=CC=C[CH]1[Fe][CH]1C=CC=C1[P](C(C)(C)C)(C(C)(C)C)->[Pd]1(<-[NH2]c2ccccc2-c2cccc[c]21)[O]S(C)(=O)=O)C(C)(C)C.CS(C)=O>CCCCc1ccc(C#Cc2cccnc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 27751321-Butyl-4-ethynylbenzene

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 27751321-Butyl-4-ethynylbenzeneHCID 178440834HCID 178440834, compound

Reagents, catalysts & solvents 3

HCID 3856267tert-Butylimino-tri(pyrrolidino)phosphoraneReagentHCID 178454865HCID 178454865, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-aa5a283544d347f8b0f092b79e985c12
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

Loading…