3-Bromopyridine → Biphenyl

HRID 1287133Notes

Reaction equation

HRID 1287133 reaction equation
Brc1cccnc1.C#Cc1ccc(CCCC)cc1>CC(C1=C([P](C2CCCCC2)(C2CCCCC2)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(C)(=O)=O)[CH]([Fe][CH]2C=CC=C2)C=C1)P(C(C)(C)C)C(C)(C)C.CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C.CS(C)=O>CCCCc1ccc(C#Cc2cccnc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 27751321-Butyl-4-ethynylbenzene

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 27751321-Butyl-4-ethynylbenzeneHCID 178440834HCID 178440834, compound

Reagents, catalysts & solvents 3

HCID 35138512-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amineReagentHCID 178437371HCID 178437371, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-64830a31c9ad4b74846a2d7a96a7f4bd
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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