Sodium → HCID 152745163, compound

HRID 1287387Notes

Reaction equation

HRID 1287387 reaction equation
[Na].Cl.[C:3]([NH2:9])(=[NH:8])[CH2:4][CH2:5][CH2:6][CH3:7].[CH2:10]([O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]=[C:25]=[O:26])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CC(C)=O>[CH2:10]([O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[NH:24][C:25]([NH:8][C:3](=[NH:9])[CH2:4][CH2:5][CH2:6][CH3:7])=[O:26])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 5360545SodiumHCID 11615174Pentanimidamide HydrochlorideHCID 1837346476813-81-5

Product 1

HCID 152745163HCID 152745163, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

Following a procedure similar to that described in Example 1 but using 2.9 g. sodium in 300 ml. dry acetone, 17.7 g. valeramidine hydrochloride, and 29.3 g. 2-(benzyloxy)phenyl isocyanate in 200 ml. dry acetone, there was obtained after recrystallization from isopropyl alcohol 33.9 g. of the hydrochloride of 1-[2-(benzyloxy)phenyl]-3-(pentanimidoyl)urea; m.p. 145°-147°C.

Workup

  1. customafter recrystallization from isopropyl alcohol 33.9 g

Sources & evidence

ORD record
ord-afca6e9f54dc42189e391d4362bcb184
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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