Acetone → HCID 178444019, compound

HRID 1287401Notes

Reaction equation

HRID 1287401 reaction equation
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[Cl:16][C:17]1[CH:18]=[C:19]([N:24]=[C:25]=[S:26])[CH:20]=[CH:21][C:22]=1[Cl:23]>C1C=CC=CC=1.CCCCC>[Cl:16][C:17]1[CH:18]=[C:19]([NH:24][C:25]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:26])[CH:20]=[CH:21][C:22]=1[Cl:23]

Participants

6

Reactant 4

HCID 180Acetone2×HCID 230651,2-Dichloro-4-isothiocyanatobenzeneHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

Product 1

HCID 178444019HCID 178444019, compound

Reagents, catalysts & solvents 1

HCID 19707280Benzene n-pentaneSolvent

Procedure

Following a procedure similar to that described in Example 42 but using 2.3 g. sodium in 250 ml. dry acetone, 16.4 g. heptanamidine hydrochloride, and 20.4 g. 3,4-dichlorophenyl isothiocyanate (b.p. 149-152/15-16 mm.) in 150 ml. dry acetone there was obtained 1-(3,4-dichlorophenyl)-3-(heptanimidoyl)-2-thiourea, m.p. 89°-90°C. (from benzene-n-pentane); hydrochloride (27 g.), m.p. 158°-160°C. (from acetonitrile).

Sources & evidence

ORD record
ord-a52a41c90bf44443947889596549e339
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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