反应详情

Following a procedure similar to that described in Example 42 but using 2.3 g. sodium in 250 ml. dry acetone, 16.4 g. heptanamidine hydrochloride, and 20.4 g. 3,4-dichlorophenyl isothiocyanate (b.p. 149-152/15-16 mm.) in 150 ml. dry acetone there was obtained 1-(3,4-dichlorophenyl)-3-(heptanimidoyl)-2-thiourea, m.p. 89°-90°C. (from benzene-n-pentane); hydrochloride (27 g.), m.p. 158°-160°C. (from acetonitrile).