Acetone → HCID 178443512, compound

HRID 1287404Notes

Reaction equation

HRID 1287404 reaction equation
[Na].CC(C)=O.Cl.[C:7]([NH2:17])(=[NH:16])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[S:27])=[CH:21][CH:20]=1>C1C=CC=CC=1.CCCCCC>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:16][C:7](=[NH:17])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[S:27])=[CH:21][CH:20]=1

Participants

6

Reactant 4

HCID 180Acetone2×HCID 164804-Chlorophenyl isothiocyanateHCID 5360545SodiumHCID 20095019HCID 20095019, compound

Product 1

HCID 178443512HCID 178443512, compound

Reagents, catalysts & solvents 1

HCID 110624Benzene hexaneSolvent

Procedure

Following a procedure similar to that described in Example 42 but using 1.9 g. sodium in 200 ml. dry acetone, 16 g. nonanamidine hydrochloride, and 14.2 g. 4-chlorophenyl isothiocyanate in 100 ml. dry acetone there was obtained 1-(4-chlorophenyl)-3-(nonanimidoyl)-2-thiourea, m.p. 102°-103°C. (from benzene-n-hexane); hydrochloride (16.2 g.); m.p. 172°-174°C. (from acetonitrile).

Sources & evidence

ORD record
ord-4ae5f7d5f08a40be8bc6284fde572b10
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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