Acetone → HCID 178444014, compound

HRID 1287405Notes

Reaction equation

HRID 1287405 reaction equation
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]=[C:24]=[S:25]>C1C=CC=CC=1.CCCCCC>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH:23][C:24]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:25]

Participants

6

Reactant 4

HCID 180Acetone2×HCID 1231711-Chloro-2-isothiocyanatobenzeneHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

Product 1

HCID 178444014HCID 178444014, compound

Reagents, catalysts & solvents 1

HCID 110624Benzene hexaneSolvent

Procedure

Following a procedure similar to that described in Example 42 but using 3.4 g. sodium in 300 ml. acetone, 24.7 g. heptanamidine hydrochloride, and 25.9 g. 2-chlorophenyl isothiocyanate (b.p. 70°-74°C./0.5-1.0 mm.; prepared from 2-chloroaniline) in 125 ml. dry acetone there was obtained 1-(2-chlorophenyl)-3-(heptanimidoyl)-2-thiourea, m.p. 75°-77°C. (from benzene-n-hexane); hydrochloride (33.5 g.), m.p. 158°-160°C. (from acetonitrile).

Sources & evidence

ORD record
ord-b4ccdd8ee39f420da929def58bdab3aa
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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