Acetone → HCID 178444030, compound

HRID 1287406Notes

Reaction equation

HRID 1287406 reaction equation
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[CH3:16][S:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[S:26])=[CH:20][CH:19]=1>C1C=CC=CC=1.CCCCC>[CH3:16][S:17][C:18]1[CH:19]=[CH:20][C:21]([NH:24][C:25]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:26])=[CH:22][CH:23]=1

Participants

6

Reactant 4

HCID 180Acetone2×HCID 5191854-(Methylthio)phenyl isothiocyanateHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

Product 1

HCID 178444030HCID 178444030, compound

Reagents, catalysts & solvents 1

HCID 19707280Benzene n-pentaneSolvent

Procedure

Following a procedure similar to that described in Example 42 but using 3.4 g. sodium in 500 ml. dry acetone, 24.7 g. heptanamidine hydrochloride, and 27.2 g. 4-(methylthio)phenyl isothiocyanate (m.p. 60°-61°C.; prepared from 4-methylthioaniline) in 120 ml. dry acetone there was obtained 1-[4-(methylthio)phenyl]-3-(heptanimidoyl)-2-thiourea, m.p. 100°-101°C. (from benzene-n-pentane); hydrochloride (43.5 g.), m.p. 181°-182°C.

Sources & evidence

ORD record
ord-1d891f856f17474aaf7ef437607660d5
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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