Acetone → HCID 178444016, compound

HRID 1287407Notes

Reaction equation

HRID 1287407 reaction equation
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[F:16][C:17]([F:28])([F:27])[C:18]1[CH:19]=[C:20]([N:24]=[C:25]=[S:26])[CH:21]=[CH:22][CH:23]=1>C1C=CC=CC=1.CCCCCC>[F:16][C:17]([F:27])([F:28])[C:18]1[CH:19]=[C:20]([NH:24][C:25]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:26])[CH:21]=[CH:22][CH:23]=1

Participants

6

Reactant 4

HCID 180Acetone2×HCID 1372321-Isothiocyanato-3-(trifluoromethyl)benzeneHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

Product 1

HCID 178444016HCID 178444016, compound

Reagents, catalysts & solvents 1

HCID 110624Benzene hexaneSolvent

Procedure

Following a procedure similar to that described in Example 42 and using 3.4 g. sodium in 350 ml. dry acetone, 24.7 g. heptanamidine hydrochloride, and 30.4 g. 3-(trifluoromethyl)phenyl isothiocyanate [b.p. 50°-52°C./0.05-0.08 mm.; prepared from 3-(trifluoromethyl)aniline] in 150 ml. dry acetone there was obtained 1-[3-(trifluoromethyl)phenyl]-3-(heptanimidoyl)-2-thiourea, m.p. 105°-107°C. (from benzene-n-hexane); hydrochloride (34.4 g.), m.p. 154°-155°C. (from acetonitrile).

Sources & evidence

ORD record
ord-e532201754714fbb9c8d3d20b22306e8
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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