4-Chlorophenyl isothiocyanate → HCID 178444018, compound

HRID 1287411Notes

Reaction equation

HRID 1287411 reaction equation
[Na].Cl.[CH2:3]([CH:5]([CH2:10][CH3:11])[CH2:6][C:7]([NH2:9])=[NH:8])[CH3:4].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]=[C:20]=[S:21])=[CH:15][CH:14]=1>CC(C)=O>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20]([NH:8][C:7](=[NH:9])[CH2:6][CH:5]([CH2:10][CH3:11])[CH2:3][CH3:4])=[S:21])=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 164804-Chlorophenyl isothiocyanateHCID 5360545SodiumHCID 21508134HCID 21508134, compound

Product 1

HCID 178444018HCID 178444018, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

Following a procedure similar to that described in Example 42 but using 3.8 g. sodium in 350 ml. dry acetone, 27.2 g. 3-ethylvaleramidine hydrochloride, and 27 g. 4-chlorophenyl isothiocyanate in 175 ml. dry acetone there was obtained 1-(4-chlorophenyl)-3-(3-ethylpentanimidoyl)-2-thiourea; m.p. 116°-118°C. (from acetonitrile); hydrochloride (42.7 g.).

Sources & evidence

ORD record
ord-c578eb97ae2145a5a9a4251e69f734c1
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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