Diethyl (ethoxymethylene)malonate → HCID 21508898, compound

HRID 1287422Notes

Reaction equation

HRID 1287422 reaction equation
CCO[CH:4]=[C:5]([C:11]([O:13]CC)=O)[C:6]([O:8][CH2:9][CH3:10])=[O:7].[CH3:16][O:17][C:18]1[CH:19]=[CH:20][C:21]2[O:26][CH2:25][CH:24]([CH3:27])[NH:23][C:22]=2[CH:28]=1>>[CH3:16][O:17][C:18]1[C:28]2[C:11](=[O:13])[C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:23]3[CH:24]([CH3:27])[CH2:25][O:26][C:21]([C:22]=23)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 21508901HCID 21508901, compound

Product 1

HCID 21508898HCID 21508898, compound

Procedure

Using the method of Example 1 diethyl ethoxymethylene malonate is reacted with 3,4-dihydro-6-methoxy-3-methyl-2H-1,4-benzoxazine and the product reacted with polyphosphoric acid to provide ethyl 2,3-dihydro-8-methoxy-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate, m.p. 165°-168° C.

Sources & evidence

ORD record
ord-71f4a37569974de5b962a1830613876d
Source dataset
uspto-grants-1976_10
Patent number
US03984548

Reaction notes

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