Hydrochloric Acid → HCID 20358452, compound

HRID 1287425Notes

Reaction equation

HRID 1287425 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([Cl:12])[C:9]=2[Cl:11])[CH2:4][CH:3]1[CH:18]([CH3:20])[CH3:19].[OH-:21].[Na+].[CH2:23]=O.Cl>O>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([Cl:12])[C:9]=2[Cl:11])[CH2:4][C:3]1([CH2:23][OH:21])[CH:18]([CH3:20])[CH3:19]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 40499{[6,7-Dichloro-1-oxo-2-(propan-2-yl)-2,3-dihydro-1H-inden-5-yl]oxy}acetic acid

Product 1

HCID 20358452HCID 20358452, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of (1-oxo-2-isopropyl-6,7-dichloro-5-indanyloxy)acetic acid (3.17 g., 0.01 mole) and sodium hydroxide (0.5 g., 0.0125 mole) in water (90 ml.) is added aqueous formaldehyde (1 ml., 0.012 mole). The resulting solution is stirred at 20°-25° C. for 41/2 days and acidified with hydrochloric acid. There is obtained 2.5 g. of (1-oxo-2-hydroxymethyl-2-isopropyl-6,7-dichloro-5-indanyloxy)acetic acid which melts at 200°-202° C. after recrystallization from ethanol-water.

Workup

  1. customThere is obtained 2.5 g
  2. customof (1-oxo-2-hydroxymethyl-2-isopropyl-6,7-dichloro-5-indanyloxy)acetic acid which melts at 200°-202° C. after recrystallization from ethanol-water

Sources & evidence

ORD record
ord-f338d44651cf4cd6a82940c59b9ef1bc
Source dataset
uspto-grants-1976_10
Patent number
US03984465

Reaction notes

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