Lithium Bromide → 2-Ethylidene-2',3'-dichloro4'-methoxypropiophenone

HRID 1287455Notes

Reaction equation

HRID 1287455 reaction equation
Br[C:2]([CH3:17])([CH2:15][CH3:16])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([Cl:13])[C:6]=1[Cl:14])=[O:4].[Br-].[Li+]>CN(C=O)C>[CH:15](=[C:2]([CH3:17])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([Cl:13])[C:6]=1[Cl:14])=[O:4])[CH3:16]

Participants

4

Reactant 2

HCID 82050Lithium BromideHCID 203584392-Bromo-2-methyl-2',3'-dichloro-4'-methoxybutyrophenone

Product 1

HCID 536319312-Ethylidene-2',3'-dichloro4'-methoxypropiophenone

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By following the procedure described in Example 5, Step C, using as the reactants 2-bromo-2-methyl-2',3'-dichloro-4'-methoxybutyrophenone (34 g., 0.1 mole), lithium bromide (17.4 g., 0.2 mole) and DMF (200 ml.), there is obtained 2-ethylidene-2',3'-dichloro-4'-methoxypropiophenone.

Sources & evidence

ORD record
ord-a969128b6b1c4a8489c202310c309f4a
Source dataset
uspto-grants-1976_10
Patent number
US03984465

Reaction notes

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