Potassium Carbonate → HCID 12761158, compound

HRID 1287461Notes

Reaction equation

HRID 1287461 reaction equation
[CH:1]1([C:6]2([CH3:19])[CH2:14][C:13]3[C:8](=[C:9]([Cl:17])[C:10]([Cl:16])=[C:11]([OH:15])[CH:12]=3)[C:7]2=[O:18])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:27][CH2:28][CH2:29][C:30]([O:32]CC)=[O:31].[OH-].[Na+]>O.CN(C=O)C>[O:18]=[C:7]1[C:8]2[C:13](=[CH:12][C:11]([O:15][CH2:27][CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[C:10]([Cl:16])[C:9]=2[Cl:17])[CH2:14][C:6]1([CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)[CH3:19]

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 76300Ethyl 4-bromobutyrateHCID 123955886,7-Dichloro-2-cyclopentyl-5-hydroxy-2-methylindan-1-one

Product 1

HCID 12761158HCID 12761158, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

By following the procedure described in Example 5, Step G, using as the reactants 2-cyclopentyl-2-methyl-5-hydroxy-6,7-dichloro-1-indanone (30.9 g., 0.1 mole), potassium carbonate (15.2 g., 0.11 mole), DMF (200 ml.), ethyl 4-bromobutyrate (23.5 g., 0.11 mole), water (200 ml.) and 10 N sodium hydroxide (40 ml.), there is obtained 4-(1-oxo-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanyloxy)butyric acid.

Sources & evidence

ORD record
ord-61b2795cc0ce4011a9256fffcd05cf90
Source dataset
uspto-grants-1976_10
Patent number
US03984465

Reaction notes

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