Ethanol → HCID 21506092, compound

HRID 1287774Notes

Reaction equation

HRID 1287774 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:18](=[O:21])(=[O:20])[NH2:19])[C:10]=1[NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:5]([OH:7])=[O:6].[CH2:22](Br)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[CH2:30](O)[CH3:31]>>[CH2:30]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([S:18](=[O:21])(=[O:20])[NH2:19])[C:10]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:2]([NH:1][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:3]=1)[CH3:31]

Participants

4

Reactant 3

HCID 702EthanolHCID 7498Benzyl BromideHCID 21506098HCID 21506098, compound

Product 1

HCID 21506092HCID 21506092, compound

Procedure

A mixture of 3 -amino-4-anilino-5-sulphamyl-benzoic acid (2 g), benzyl bromide (3 g), and ethanol (50 ml 99.9%) was refluxed for 8 hours. After cooling, the ethyl-4-anilino-3-benzylamino-5-sulphamyl-benzoate crystallized and was collected by suction. After recrystallization from ethanol the melting point was 160°-161° C.

Workup

  1. temperaturewas refluxed for 8 hours
  2. temperatureAfter cooling
  3. customthe ethyl-4-anilino-3-benzylamino-5-sulphamyl-benzoate crystallized
  4. customwas collected by suction
  5. customAfter recrystallization from ethanol the melting point was 160°-161° C.

Sources & evidence

ORD record
ord-233464decfd14948b5fe9efcf4bc56e4
Source dataset
uspto-grants-1976_10
Patent number
US03985777

Reaction notes

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