反应详情

A mixture of 3-amino-5-sulphamyl-4-(m-trifluoromethylphenoxy)-benzoic acid (1.82 g), benzyl bromide (2 g), and anhydrous ethanol (15 ml) was refluxed for 7 hours. The solution was cooled, and the precipitated ethyl 3-benzylamino-5-sulphamyl-4-(m-trifluoromethylphenoxy)benzoate was collected by suctin. After recrystallizatin from ethanol, the melting point was 166°-168° C.

1. temperaturewas refluxed for 7 hours
2. temperatureThe solution was cooled
3. customthe precipitated ethyl 3-benzylamino-5-sulphamyl-4-(m-trifluoromethylphenoxy)benzoate was collected by suctin