Hydrochloric Acid → HCID 86734074, compound

HRID 1287818Notes

Reaction equation

HRID 1287818 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].C1(NC2CCCCC2)CCCCC1.[S:21]1[CH:25]=[CH:24][CH:23]=[C:22]1[C:26]([OH:28])=[O:27].O.Cl>C(OCC)(=O)C>[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].[S:21]1[CH:25]=[CH:24][CH:23]=[C:22]1[C:26]([OH:28])=[O:27]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86734073HCID 86734073, compound

Product 1

HCID 86734074HCID 86734074, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

11.7 g. (0.033 mole) of 4,5-dimethylthiazole-2-thiolcarboxylic acid dicyclohexylamine salt, dissolved in 175 ml. of water and 175 ml. of ethyl acetate, was cooled and acidified with 6N hydrochloric acid to pH 2.2. The layers were separated and the aqueous phase was extracted with 2 × 75 ml. of ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered and evaporated under reduced pressure yielding 4.6 g. (80%) of a red solid. Infrared spectrum was consistent with the desired material.

Workup

  1. customThe layers were separated
  2. extractionthe aqueous phase was extracted with 2 × 75 ml
  3. dry with materialThe combined organic phases were dried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated under reduced pressure
  6. customyielding 4.6 g

Sources & evidence

ORD record
ord-364e8ec71fb9429c822e1aa4b9931f3e
Source dataset
uspto-grants-1976_10
Patent number
US03985740

Reaction notes

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