Sulfuryl chloride → HCID 53680523, compound

HRID 1287847Notes

Reaction equation

HRID 1287847 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:11]([NH:23][C:24](=[O:26])[CH3:25])[CH:10]=1)=[O:8].[Na].[S:28](Cl)([Cl:31])(=[O:30])=[O:29]>C1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[C:11]([N:23]([S:28]([Cl:31])(=[O:30])=[O:29])[C:24](=[O:26])[CH3:25])[CH:10]=1)=[O:8]

Participants

5

Reactant 3

HCID 24648Sulfuryl chlorideHCID 5360545SodiumHCID 53916260N-[2-(Benzyloxy)-5-(pyridine-2-carbonyl)phenyl]acetamide

Product 1

HCID 53680523HCID 53680523, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

An anhydrous benzene solution of 3-acetamido-4-benzyloxyphenyl 2-pyridyl ketone is heated at reflux with sodium until a suspension is formed. To this suspension is added sulfuryl chloride in benzene and the resulting mixture is filtered to remove sodium chloride. The filtrate is evaporated to give 4-benzyloxy-3-(N-chlorosulfonylacetamido)phenyl 2-pyridyl ketone.

Workup

  1. customis formed
  2. filtrationthe resulting mixture is filtered
  3. customto remove sodium chloride
  4. customThe filtrate is evaporated

Sources & evidence

ORD record
ord-d60b15a2f1a14c9589b857e64d02e222
Source dataset
uspto-grants-1976_10
Patent number
US03985887

Reaction notes

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