4-Chlorobenzaldehyde → HCID 53689253, compound

HRID 1287865Notes

Reaction equation

HRID 1287865 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[CH2:10]([O:12][C:13](=[O:20])[CH:14]=[C:15]([NH2:19])[O:16][CH2:17][CH3:18])[CH3:11]>>[CH2:10]([O:12][C:13]([C:14]1[CH:6]([C:5]2[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH:14]([C:13]([O:12][CH2:10][CH3:11])=[O:20])[C:15]([O:16][CH2:17][CH3:18])=[N:19][C:15]=1[NH2:19])=[O:20])[CH3:11]

Participants

3

Reactant 2

HCID 77264-ChlorobenzaldehydeHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl ester

Product 1

HCID 53689253HCID 53689253, compoundYield 56%

Procedure

Boiling a solution of 7.1 g of 4-chlorobenzaldehyde and 15.9 g of 3-amino-3-ethoxyacrylic acid ethyl ester in 50 ml of alcohol for 8 hours yields 2-amino-4-(4-chlorophenyl)-6-ethoxy-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester of melting point 130°-132° C (ethyl acetate/petroleum ether). Yield: 56% of theory.

Workup

  1. customfor 8 hours

Sources & evidence

ORD record
ord-55249c5eee6b4d38bccb83e0af41f745
Source dataset
uspto-grants-1976_10
Patent number
US03985886

Reaction notes

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