4-Chloro-6-fluoro-2-methylquinoline → 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

HRID 1287883Notes

Reaction equation

HRID 1287883 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([F:12])[CH:10]=2)[N:5]=[C:4]([CH3:13])[CH:3]=1>[Rh]>[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[NH:5][CH:4]([CH3:13])[CH2:3][CH2:2]2

Participants

3

Reactant 1

HCID 876944-Chloro-6-fluoro-2-methylquinoline

Product 1

HCID 5916846-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

Reagents, catalysts & solvents 1

HCID 23948RhodiumCatalyst

Procedure

4-Chloro-6-fluoroquinaldine was reduced with rhodium on carbon to give 6-fluoro-2-methyltetrahydroquinoline.

Sources & evidence

ORD record
ord-50d02a222b7c477d87f05445bf215990
Source dataset
uspto-grants-1976_10
Patent number
US03985882

Reaction notes

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