Potassium 2-ethylhexanoate → HCID 131710494, compound

HRID 1287990Notes

Reaction equation

HRID 1287990 reaction equation
[CH3:1][O:2][N:3]=[CH:4][C:5]1[CH2:6][S:7][C@@H:8]2[C@H:15]([NH:16][C:17](=[O:24])[CH2:18][C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)[C:14](=[O:25])[N:9]2[C:10]=1[C:11]([OH:13])=[O:12].C(C(CCCC)C([O-])=O)C.[K+:36]>C(OCC)(=O)C.C(O)CC>[OH2:2].[CH3:1][O:2][N:3]=[CH:4][C:5]1[CH2:6][S:7][C@@H:8]2[C@H:15]([NH:16][C:17](=[O:24])[CH2:18][C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)[C:14](=[O:25])[N:9]2[C:10]=1[C:11]([O-:13])=[O:12].[K+:36]

Participants

5

Reactant 2

HCID 23669619Potassium 2-ethylhexanoateHCID 131710493HCID 131710493, compound

Product 1

HCID 131710494HCID 131710494, compoundYield 181.3%

Reagents, catalysts & solvents 2

HCID 10311-PropanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 3-methoxyiminomethyl-7β-(2-thienylacetamido)-3-cephem-4-carboxylic acid (10.1 g) in ethyl acetate (50 ml) is added a solution of potassium 2-ethylhexanoate (4.5 g) in propanol (8.9 ml), and the mixture is kept in a refrigerator for 15 hours. The crystals formed are collected by filtration, washed with ethyl acetate, and recrystallized from a mixture of methanol and ether to give potassium 3-methoxyiminomethyl-7β-(2-thienylacetamido)-3-cephem-4-carboxylate monohydrate (10.5 g). m.p. 206°-209° C. Yield: 91%.

Workup

  1. customThe crystals formed
  2. filtrationare collected by filtration
  3. washwashed with ethyl acetate
  4. customrecrystallized from a mixture of methanol and ether

Sources & evidence

ORD record
ord-6c3274b7cc19478486ca043578788aa2
Source dataset
uspto-grants-1976_10
Patent number
US03987039

Reaction notes

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