Hydrochloric Acid → HCID 21503555, compound

HRID 1288155Notes

Reaction equation

C(OC([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH:8]([O:22]C(OCC)=O)[CH2:7]1)=O)C.[ClH:28]>>[ClH:28].[ClH:28].[OH:22][CH:8]1[C:9]2=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]([CH3:21])=[C:18]2[CH2:19][CH2:20][NH:6][CH2:7]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 53930117HCID 53930117, compound

Product 1

HCID 21503555HCID 21503555, compoundYield 68%

Procedure

1,2,4,5-Tetrahydro-5-hydroxy-11-methyl-3H-azepino[4,5-b]quinoline dihydrochloride was prepared from 5-(ethoxycarbonyloxy)-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester by hydrolysis with 2 N hydrochloric acid for 36 hours at the boiling point. After distilling off the hydrochloric acid, the remaining water was removed by entrainment with benzene, and the raw salt was recrystallized from methanol.

Workup

distillationAfter distilling off the hydrochloric acid
customthe remaining water was removed by entrainment with benzene
customthe raw salt was recrystallized from methanol

Sources & evidence

ORD record: ord-baaa9391870c42eb8f6ede9532c7d8e9
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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