Hydrochloric Acid → HCID 53813451, compound

HRID 1288161Notes

Reaction equation

HRID 1288161 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][C:14]([N+:22]([O-])=O)=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH2:8][CH2:7]1)=[O:5])[CH3:2].[H][H].Cl.[Sn](Cl)Cl>>[CH2:1]([O:3][C:4]([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][C:14]([NH2:22])=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 24479Stannous ChlorideHCID 53994340HCID 53994340, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 53813451HCID 53813451, compoundYield 95%

Procedure

9-Amino-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester was prepared from 9-nitro-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester by reduction with nascent hydrogen, generated in situ by concentrated hydrochloric acid and tin(II)chloride, at a temperature of 60°-80° C.

Sources & evidence

ORD record
ord-8424d84b530d416bb11331649fcb0baf
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

Loading…