Ethyl chloroacetate → HCID 68139344, compound

HRID 1288180Notes

Reaction equation

HRID 1288180 reaction equation
[Cl:1][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH3:8][C:9]1[C:18]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N:12]=[C:11]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23][C:10]=12>C1C=CC=CC=1.C(N(CC)CC)C>[ClH:1].[ClH:1].[CH2:6]([O:5][C:3](=[O:4])[CH2:2][N:21]1[CH2:22][CH2:23][C:10]2[C:11](=[N:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:9]=2[CH3:8])[CH2:19][CH2:20]1)[CH3:7]

Participants

5

Reactant 2

HCID 7751Ethyl chloroacetateHCID 304399911-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]quinoline

Product 1

HCID 68139344HCID 68139344, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 8471TriethylamineSolvent

Procedure

15 ml (141 millimols) of ethyl chloroacetate were added dropwise to a boiling solution of 30 gm (141 millimols) of 1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline in 200 ml of benzene and 20 ml of triethylamine. After filtering off the precipitated triethylamine hydrochloride, the solvent was distilled off, and the residual base was converted into the dihydrochloride in ethanol with ethanolic hydrochloric acid.

Workup

  1. filtrationAfter filtering off the precipitated triethylamine hydrochloride
  2. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-1af9143ccfde4c70ad1cdc82c0610cda
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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