反应详情

A mixture of 4-chloro-3-methylphenol (100 g.) and 1,2-dibromoethane (158.2 g.) in water (160 ml.) was stirred and heated to reflux during the slow dropwise addition of a solution of sodium hydroxide (30.8 g.) in water (140 ml.). Stirring and heating were continued for a total of 6 hours and the mixture was cooled and extracted exhaustively with ether. The ethereal extract was washed exhaustively with 5N-sodium hydroxide, dried over potassium carbonate, filtered and evaporated. The residual oil was distilled under reduced pressure to give 1-bromo-2-(4-chloro-3-methylphenoxy)ethane, b.p. 106°-112° 10.65 mm.

1. temperatureheated
2. stirringStirring
3. temperatureheating
4. customwere continued for a total of 6 hours
5. temperaturethe mixture was cooled
6. extractionextracted exhaustively with ether
7. extractionThe ethereal extract
8. washwas washed exhaustively with 5N-sodium hydroxide
9. dry with materialdried over potassium carbonate
10. filtrationfiltered
11. customevaporated
12. distillationThe residual oil was distilled under reduced pressure