反应详情

To a stirred solution of 1-chloro-4-hydroxynonane (Example A, Step 2) (11.0 g., 0.062 mole) and dihydropyrane (5.2 g., 0.062 mole), cooled in an ice bath is added 5 drops of hydrochloric acid (conc.). A slight exothermic reaction is noted and when this is complete the reaction is allowed to come to room temperature then stand at this temperature for 2 hours. At the end of this period, several pellets of sodium hydroxide are added and the reaction is distilled in vacuo. The yield of 1-chloro-4-(2-tetrahydropyranyloxy)nonane is 12.5 g. (77%), boiling 96°-102°C./0.1 mm. Upon redistillation, a boiling point of 90°-92°C./0.1 mm. is obtained.

1. customA slight exothermic reaction
2. customto come to room temperature
3. distillationthe reaction is distilled in vacuo
4. customboiling 96°-102°C.
5. distillationUpon redistillation
6. customis obtained